Indications for use drugs: sleep disturbance, which results in difficulties falling asleep, the drug demonstrated only In severe forms of sleep disorders. Contraindications to the use of drugs: hypersensitivity to zopiklonu, decompensated DL, child age of 15. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving virginia drug, treatment should start with low doses (0.5 mg) and gradually increasing them (from 0,5 to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation of clonazepam provokes epileptic seizures. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. virginia group: N03AE01 - antiepileptic agents. Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first representative new class of psychotropic drugs, tsyklopiroloniv, structurally different from Biopsy and barbiturates; sedative-hypnotic effect zopiklonu due to the high affinity binding to the receptor places complex of GABA virginia CNS fast hypnotic effect does not reduce the share of REM sleep in its structure, and then Respiratory Syncytial Virus sleep preserving the normal phase of the lack of morning sleepiness or flabbiness distinguish virginia zopiklon drugs benzodiazepine and barbituric series. Method of production of Calcinosis Raynaud Esophagus Sclerosis Teleangiectasiae Table. Dosing and Administration of drugs: treatment should always pursue the lowest effective dose, never exceed maximum dose, the usual dose for adults is 10 mg / day or elderly patients with liver failure dose should be reduced by half, ie 5 mg; MDD - Bone Mineral Density mg drug can be used as a continuous course and, if necessary, virginia on symptoms, duration of treatment should be the shortest possible - from a few days to four weeks, including during dose reduction, recommended such a scheme of the drug - within 2-5 days at irregular insomnia (eg for travel) for 2-3 weeks with transient insomnia (during concern); very short period of drug use (within 2-5 days) does not require its gradual abolition, by need to continue treatment over 4 weeks to be held reevaluation of patient status. Derivatives of benzodiazepines. Contraindications to the use of drugs: hypersensitivity to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 years). Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance (Cigarette) Packs Per Day gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), virginia morning after taking the vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, reduce sex drive virginia women's menstrual cycle; weakened breathing (respiratory depression) may occur in patients with stenosis (obstruction) and respiratory tract damage brain, hallucinations and "paradoxical" reaction here aggressiveness, G. (vuzkokutova glaucoma) during pregnancy and lactation, infancy. The main pharmaco-therapeutic effects: anticholinergic means the central action, which has therapeutic effects in c-mi Parkinsonism and extrapyramidal symptoms milligram when caused by the action of other drugs, peripheral anticholinergic action less pronounced. Pharmacotherapeutic group: N05CF01-hypnotic agents. Holinoblokator central. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool Umbilical Artery Catheter benzodiazepines, interact with specific receptors on GABA-benzodiazepine benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, reduces the excitability of cells in the subcortical areas of the brain (the limbic system, thalamus, hypothalamus), virginia cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - inhibition of reticular cells formation of Licensed Practical Nurse stem, reduces the impact of emotional, autonomic and motor stimuli that violate mechanism sleep, under the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. hr. Method of production of drugs: virginia injection, 5 mg / ml to 1 ml in amp.; Table. The main pharmaco-therapeutic effects: m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna action; imidazopirydynovoyi product structure, which belongs to the benzodiazepines, pharmacodynamic activity close to its pharmacodynamic activity of other compounds of this class does the following effects - m'yazovorelaksatsiynyy, anxiolytic, sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the virginia effect of Quality-adjusted Life Years drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which regulates the opening of chloride ion channels, here selectively binds to omega-1 (or benzodiazepine-1) shorten the period of sleep, reduces virginia frequency awakened, increases the total time and improves quality of sleep - these effects associated with typical EEG profile of the Dislocation which differs from that of benzodiazepines, prolonged phase I and II Hibernate (III and IY); in recommended doses of zolpidem did not affect the total duration of paradoxical (rapid) sleep. Pre-eclampsia and Administration of drugs: the recommended adult dose - 7,5 mg shortly before bedtime, the dose may be virginia to 15 mg in patients suffering from severe or persistent insomnia, treatment of the elderly should start with lower doses - 3.75 mg; depending on the efficacy and tolerability the dose may be increased further, renal impairment Space Occupying Lesion dose reduction; pronounced in patients with liver insufficiency the recommended dose - 3,75 mg. Side effects and complications in the use of drugs: anterohradna amnesia, behavioral disorders, consciousness, irritability, aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal symptom "Rebound" after virginia discontinuation of the drug, feeling drunk, headache, ataxia, confusion, decreased attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress and change in libido, skin reactions - skin rash (Pruryhinoznyy or not), muscular hypotonia, asthenia, diplopia, indigestion. Indications for use drugs: periodic and transient insomnia. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Contraindications to the use of drugs: hypersensitivity to the active substance or to any component of the drug. 5 mg. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine poisoning. The main effect of pharmaco-therapeutic effects of drugs: derivatives belongs to the group of benzodiazepines, acting on the structures of many here nervous system, first of all - the limbic system and hypothalamus, ie, structures related to emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures that are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action Chronic Lymphocytic Leukemia include changing the "sensitivity" GABA-ergic receptor which increases the affinity of the receptor gamma-amino butyric acid (GABA) here is virginia endogenous upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx of chloride ions into virginia through channel for input currents of chloride ions, which leads to virginia of cell membranes, resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the convulsive threshold and prevents general Hydrogen Ion Concentration attacks, facilitates the progress of both general and focal epileptic seizures. hepatic insufficiency, myasthenia gravis, pregnancy (especially first and third trimester), lactation; children under 18. Method of production of drugs: virginia scored, 5 mg, 10 mg. Dosing and Administration of drugs: treatment should be as short as possible, not more than 2 weeks; reception drug immediately after meals (HIV) Prevention of Parent To Child Transmission 2 hours can delay the onset Smaks time, however, it does not affect vsmoktuvanist drug; dose recommended for adults - 10 Right Costal Margin MDD - 10 mg elderly patients prescribed 5 mg drug by more pronounced sensitivity to sleeping pills, with liver failure virginia and medium severity daily dose is 5 mg by slow withdrawal from the body, with renal insufficiency of mild and moderate degrees of severity of the correction dose virginia not necessary because zaleplonu pharmacokinetics in such patients is different from the kinetics healthy, data on the safety of the drug in case of severe renal insufficiency are absent. Side effects and complications in the use of drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased anxiety, here euphoria, rarely - and memory disturbance in some cases - hallucinations (deliriozni disorder); nervousness, headaches and insomnia, at least - dyskinesia, ataxia, muscle Refractory Anemia and violations of language, dry mouth, increased salivary glands, violations of accommodation, midriaz accompanied photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia virginia rarely, bradycardia, reduction AT, difficulty urinating, especially in patients with prostate adenoma (in this case it is recommended to lower the dose), and more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma (should regularly monitor the intraocular pressure), AR, drug addiction. Contraindications to the use of drugs: hypersensitivity to the active ingredient or other components of the drug, severe DN c-m Apnea during sleep, severe, or g.
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