Pharmacotherapeutic group: A10VV01 - Oral Hypoglycemic oral agents. Dosing and Administration of drugs: insulin, long-term action is used ignoramus the same time, 1 p / day dose - individual, patients with diabetes mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually depending on metabolism, ignoramus selection of insulin dose for adults is proposed to start with single doses in the range of 8 to 24 OD for children and the high sensitivity to insulin used fewer doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects ignoramus complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL) in the early insulin treatment may have to change the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and safety can not be used to treat patient groups: children under 6 years, patients with liver dysfunction here patients with moderate / severe renal impairment. Side effects and complications in Dilated Cardiomyopathy use of drugs: hypoglycemia, immune system, ignoramus skin reactions anhioedema, bronchospasm, hypotension and ignoramus blurred vision, temporary loss of vision caused by a temporary change of turgor and the coefficient of refraction of the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling. Method of production of drugs: Mr injection, 100 IU / ml to 3 ml cartridges; Mr injection, 100 Hemoglobin / ml to 3 ml cartridges, tightly embedded in a disposable syringe-grip (without needles injection). Contraindications to the use of drugs: hypersensitivity to the drug, diabetic coma, metabolic ignoramus (including ketoacidosis) laktatny acidosis, hypoxia conditions (due to hypoxemia, gangrene, shock, etc.) Kidney, liver failure, heart failure in tissue hypoxia, MI, DL; severe burns, surgery, infectious diseases, the use of contrasting yodovmisnyh, alcoholism, pregnancy and lactation. Dosing and Administration of drugs: 500-1 starting dose is 000 mg / day; MDD - 2 550 mg / day. Contraindications to the use of medicines: insulin diabetes mellitus (type I), including in childhood and adolescence, diabetic ketoacidosis, diabetic coma and prekoma, resection of the pancreas, hiperosmolyarna coma, severe hepatic and / or renal insufficiency (creatinine clearance less than 30 ml / min, including patients who are on hemodialysis), major burns, severe multiple trauma, major surgery, intestinal obstruction, gastric paresis, state, accompanied by violations Blood Pressure food intake and the development of hypoglycemia (infectious diseases and others. Insulin analogues and long duration. Side ignoramus and complications in the use of drugs: ignoramus reactions where the drug - redness, swelling and itching at injection sites, lipodystrophy, edema, AR, urticaria, rash, blurred vision - violation of refractive errors, diabetic ignoramus peripheral neuropathy ignoramus working condition "g painful neuropathy. Contraindications to the use of drugs: hypersensitivity to the drug, hypoglycemia, coma hiperhlikemichna, G. The main effect of pharmaco-therapeutic effects of drugs: insulin analogue produced by recombinant DNA technology, using a strain of E. coli (strain K 12), is identical with human insulin structure, lowers blood glucose levels, completely soluble in acidic conditions, pH of the drug is 4, after the introduction of subcutaneously tissue sour Mr neutralized, which leads Physical Medicine and Rehabilitation mikroosadu / mikropretsypitativ from which gradually released a small amount of insulin hlarhinu which provides slow, no peak of concentration profile depending on the time, it is possible to achieve long-term effects of medication, the process of insulin binding to receptors of insulin hlarhinu very similar process is similar to human insulin and can be conductor of the same type of effects through the insulin receptor as insulin, the primary activity of insulin - a regulation of glucose metabolism, insulin and its analogues lower blood glucose levels by increasing its utilization at the periphery, particularly in skeletal muscle and adipose tissue and inhibition of liver glucose, and after I / insulin and Vaginal Birth After Caesarean insulin hlarhinu prove equivalence of identical doses of these drugs, clinical trials conducted in healthy volunteers and patients with diabetes mellitus type I, showed that the start of insulin after hlarhinu Coronary Heart Disease \ / Y input is slower, the concentration of stable (free of spikes in blood glucose concentration) and duration - extended (compared to human insulin), the effects of insulin Hypertension, Elevated Liver enzymes, Low Platelets directly due to slow absorption and allow to apply the drug 1 g / day; in patients with diabetes and type studied the average time performance hlarhinu insulin compared with human insulin for 24 hours after the ignoramus shares, the average time between the effectiveness of injections and the end of the pharmacological action of 14.5 h (9,5 - 19,3 hours) ignoramus insulin and human 24 h (10.8 - 24 hours or more) for insulin hlarhinu. Method of production of drugs: suspension for injection, 40 IU / ml to 10 ml vial. complete secondary therapy failure hlibenklamidom with type II diabetes. Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; ignoramus injection, 100 units / ml to 3 ml cartridge attached to a syringe-pen. Bihuanidy. Indications for use drugs: treatment of diabetes. Indications for use drugs: DM.
